Atherosclerosis Development Concept Map
Atherosclerosis development and its consequences Prenatal risk factors Postnatal risk factors Mother was a smoker during pregnancy Father died from a heart attack (Family history) Early birth weight Potential genetic predisposition Heavy smoker Hyperlipidaemia Moderately obese Major risk factors Need to catch up weight Toxins from cigarette smoke released (chemical insult) Change in blood constituents Ratio of total cholesterol to high density lipoproteins is 6.5 Hypertension (high blood pressure) Other risk factors Advanced Age DNA damage Shear stress to endothelial cells Endothelial cell damage (inflammatory) Increased permeability Lipid infiltration Buildup of atherosclerotic plaque Thrombus Leukocyte adhesion Endothelial cells produce endothelin Injured endothelial cells produce von Willebrand factor platelet adhesion to exposed extracellular matrix Exposed underlying connective tissue in basement membrane (Extracellular matrix) platelet activation Platelets secrete thromboxane A, vasoactive amines, and ADP Promotes vasoconstriction and platelet aggregation Activates haemostasis Promotes haemostasis Vasoconstrictio n Hypercoagulability Change in blood flow Virchow's triad Haemodynamic force of blood Epigenetic reprogramming Increased risk of developing cardiavacular disease at an earky age Change in vessel wall Pathological damage in hospital tests Low output Heart failure Disease development due to atherosclerosis Inadequate blood supply during resting (ischaemic) T-wave inversion in ECG Severe ischaemia and necrosis in heart muscle Troponin-1 and MB isotype of creatine kinase necrosis of cardiomyocytes Organ damage Nuclear degradation via necrosis of right side of brain Necrosis of gut due to infarction Lung congestion due to presence of fibrous septa (indicates fluid buildup in lungs) Embolism of blood vessels in gut Loss of function to right side of body Angina pectoris Treatment and lifestyle changes Myocardial ischaemia
publish time: 2021-05-23
Here is a concept map about atherosclerosis development and its consequences. Atherosclerosis develops over the course of 50 years, beginning in the early teenage years. Arteriosclerosis occurs when the blood vessels that carry oxygen and nutrients from your heart to the rest of your body (arteries) become thick and stiff. Learn more details from this map, or try to make yours with ease.
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